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As Na ions enter the cell, the membrane potential is further depolarized, and more voltage-gated sodium channels are activated.Such a process is also known as a positive feedback loop.

Opening of NMDA channels (which relates to the level of cellular depolarization) leads to a rise in post-synaptic Ca2 concentration and this has been linked to long-term potentiation, LTP (as well as to protein kinase activation); strong depolarization of the post-synaptic cell completely displaces the magnesium ions that block NMDA ion channels and allows calcium ions to enter a cell – probably causing LTP, while weaker depolarization only partially displaces the Mg2 ions, resulting in less Ca2 entering the post-synaptic neuron and lower intracellular Ca2 concentrations (which activate protein phosphatases and induce long-term depression, LTD).Some neurons such as photoreceptor cells, for example, do not have myelinated axons that conduct action potentials.Other unipolar neurons found in invertebrates do not even have distinguishing processes such as dendrites.When ionotropic receptors are activated, certain ion species such as Na to enter the postsynaptic neuron, which depolarizes the postsynaptic membrane.If more of the same type of postsynaptic receptors are activated, then more Na will enter the postsynaptic membrane and depolarize cell.

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Neurons are diverse with respect to morphology and function.